BMUS: The Burden of Musculoskeletal Diseases in the United States
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Home > The Burden of Musculoskeletal Diseases in the United States, Fourth Edition > Special and Rare > Neuromuscular Disorders > Motor Neuron Disorder > Impacts of Aging

Impacts of Aging

VIB.D.2

Lead Author(s): 

Jonathan S. Kirschner, MD, RMSK
Se Won Lee, MD

Supporting Author(s): 

Sylvia I. Watkins-Castillo, PhD

Incidence rates of ALS increase with age, peaking between 70 and 80 years. Amyotrophic lateral sclerosis is a fatal condition for most patients with mean life expectancy of about 3 years after diagnosis, although some patients live longer.

Poliomyelitis is a viral infection affecting the nervous system which causes motor neuron disease. Although it has been eradicated by vaccines developed in the 1950's, polio survivors can suffer from post-polio syndrome for several decades (mean of 36 years) with gradual weakness, fatigue and muscle wasting. A study published in 1994-1995 estimated there were about 1 million polio survivors in the U.S., with 443,000 reported having had paralytic polio. Considering 25 to 40 percent of polio survivors develop the post-polio syndrome, it is one of most prevalent motor neuron disease in the elderly population.1

  • 1. National Institute of Neurological Disorders and Stroke Disorder. Post-polio syndrome fact sheet: Who is at risk? https://www.ninds.nih.gov/Disorders/Patient-Caregiver-Education/Fact-She... [1]. Accessed August 1, 2017.

Edition: 

  • Fourth Edition
The Burden of Musculoskeletal Diseases in the United States - Copyright © 2014.

Source URL: https://bmus.latticegroup.com/fourth-edition/vibd2/impacts-aging

Links:
[1] https://www.ninds.nih.gov/Disorders/Patient-Caregiver-Education/Fact-Sheets/Post-Polio-Syndrome-Fact-Sheet